The universe where House of M takes place is designated as Earth-58163.
The first issue was released in June 2005, with the series concluding in November 2005. The first two issues were ranked first and second in sales in the June 2005 period, with the first issue selling over 233,000 copies. The final issue, House of M #8, was ranked third in sales for the November 2005 period with sales of 135,462. In addition to the main eight-issue limited series, House of M was preceded by a story in Excalibur #13-14, and had several tie-ins to ongoing series, including Uncanny X-Men, New X-Men: Academy X, and Wolverine, and several mini-series: Fantastic Four: House of M,The Incredible Hulk: House of M, Iron-Man: House of M, Mutopia X: House of M, and Spider-Man: House of M.
Bendis, lead writer for the House of M event, stated that the series would "shake the world and break the internet wide open." Prior to the event, Bendis also mentioned in several interviews that the event would have a lasting effect on the Marvel Universe, but remained tight-lipped as to what. The reduction of the mutant community was the only rumored effect that actually came about.
The crossover was followed by a one-shot called House of M: Decimation - The Day After, a series called Son of M that depicts Quicksilver dealing with his loss of powers, and Generation M, which devoted each issue to a different mutant dealing with his/her loss of powers. Characters who appeared include Chamber, Jubilee, and Blob. Characters who lost their powers included Dani Moonstar, Magneto, and Tag. The storyline also led to the reboot of Excalibur into New Excalibur, a shift in the creative teams of several comics, and the debut of several spin-off series, including X-Men: Deadly Genesis, X-Men: The 198, Sentinel Squad O*N*E, Ms. Marvel, and a new X-Factor series.
The epilogue to the House of M and Decimation storylines, which served to answer to the mystery of the strange "energy-cloud" hovering in orbit around the Earth at the conclusion of House of M #8, was revealed in the pages of New Avengers #16-20.
In this world, Magneto was attacked by Sentinels over Manhattan in 1979 (taking advantage of Marvel's sliding timescale policy, there are no heroes active in the 1970s). At the end of the attack, Magneto revealed an alleged international anti-mutant conspiracy involving Richard M. Nixon. The main result of this was that Magneto was granted sovereignty of the island of Genosha as the leader of the world's mutants. Another result was that the protection of mutant life was judged to be the first worry of all laws (as a result, stem cell research on mutant embryos is illegal, but stem cell research on altered human embryos is permitted). Because of this, the world is a racist society, with mutants controlling governments, businesses, and culture; and humans (or "sapiens") are looked down on as inferior (essentially a reversal of the status quo in the mainstream Marvel Universe, where mutants are looked down on and despised instead).
Some exceptions apply to "sapiens" who live with privileges like Carol Danvers (Ms. Marvel in Earth-616 continuity, but Captain Marvel in the World of M) and Peter Parker (Spider-Man). However, while Danvers is widely known to be a "sapien," Spider-Man is believed by the House of M world at large to be a mutant.
Given that the House of M reality was created by the Scarlet Witch and Charles Xavier combining their powers to give the assembled New Avengers and X-Men their heart's desires, it appears that Magneto's heart's desire was threefold. Primarily, he wanted the entire world to acknowledge that his paranoid fantasies about baseline humans wanting to exterminate mutants were true (hence the Sentinel attack over New York in 1979, which concluded with the release of evidence that the world's human leaders were involved in a genocidal anti-mutant conspiracy). Secondly, he wanted to be acknowledged as a heroic figure and the rightful leader of all mutantkind (hence the disappearance of Charles Xavier and the timing of Magneto's rise to dominance before other superheroes had appeared on the scene to challenge him). And thirdly, a massive speeding-up of the natural evolution of homo sapiens into homo superior; until, by the modern era, they accounted for almost 50% of the global population, providing him with a power base sufficient to take over the governments of the world and use them to oppress baseline humans.
It is unclear whether the Scarlet Witch's magic altered the entire Marvel Universe, or merely the structure and history of Earth, a fact further complicated by the events of Secret Invasion. The Skrull Hank Pym stated that there was no way the Skrull army could win against such a vast number of mutants, at least possibly implying the Skrull army was left intact by Wanda's reality warp. Also, Xavier's supposed death in this reality, yet with no body, combined with his own off-planet actions, further confuse the issue. However, there is a Kree ambassador called Genis-Vell that appears within this illusory reality, and the Kree are shown to be peacefully collaborating with Earth, signifying that such was the Scarlet Witch's power that she was indeed capable of rewriting all of reality, the entire universe.
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